November 24, 2014
Corresponding authors: John A. Stamatoyannopoulos, Michael P. Snyder,
Roderic Guigo, Thomas R. Gingeras, David M. Gilbert, Ross C. Hardison,
Michael A. Beer, Bing Ren
Mouse ENCODE Consortium
Nature 515, 355–364 (20 November 2014) doi:10.1038/nature13992
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To gain greater insights into both shared and species-specific transcriptional and cellular regulatory programs in the mouse, the Mouse ENCODE Consortium has mapped transcription, DNase I hypersensitivity, transcription factor binding, chromatin modifications and replication domains throughout the mouse genome in diverse cell and tissue types. By comparing with the human genome, we not only confirm substantial conservation in the newly annotated potential functional sequences, but also find a large degree of divergence of sequences involved in transcriptional regulation, chromatin state and higher order chromatin organization. Our results illuminate the wide range of evolutionary forces acting on genes and their regulatory regions, and provide a general resource for research into mammalian biology and mechanisms of human diseases.
The electronic version of this article is the complete one and can be found online at: http://www.nature.com/nature/journal/v515/n7527/full/nature13992.html
More about Mouse ENCODE Consortium:
"To complement the human Encyclopedia of DNA Elements (ENCODE) project the Mouse ENCODE Consortium (funded by the National Human Genome Research Institute from 2009-2012) applied the same technologies and experimental pipelines developed for human ENCODE in order to annotate functional elements encoded in the mouse genome. The data and analyses from Mouse ENCODE will enable a broad range of mouse genomics and translational research efforts
The Mouse ENCODE Consortium consisted of a number of Data Production Centers and made use of the human ENCODE Data Coordination Center (DCC) at the University of California, Santa Cruz (currently at Stanford University). Production Centers generally focused on different data types, including transcription factor and polymerase occupancy, DNaseI hypersensitivity, histone modification, and RNA transcription.
Work on Mouse ENCODE is continuing with further funding from the National Human Genome Research Institute under the ENCODE 3 program, which supports both human and mouse studies."
image source: http://twitter.com/nature
