May 27, 2014
Correspondence: Joshua M Nicholson jmn@vt.edu
Virginia Tech, Department of Biological Sciences, 1981 Kraft Dr, Blacksburg, VA 24060, USA
Molecular Cytogenetics 2013, 6:57 doi:10.1186/1755-8166-6-57
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Abstract
The promise to understand cancer and develop efficacious therapies by sequencing thousands of cancers has not occurred. Mutations in specific genes termed oncogenes and tumor suppressor genes are extremely heterogeneous amongst the same type of cancer as well as between cancers. They provide little selective advantage to the cancer and in functional tests have yet to be shown to be sufficient for transformation. Here I discuss the karyotyptic theory of cancer and ask if it is time for a new approach to understanding and ultimately treating cancer.
The electronic version of this article is the complete one and can be found online at: http://www.molecularcytogenetics.org/content/6/1/57
#Image Source: http://cdn.knowcancer.com
